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Some more details...

Pre-game considerations:

You will need at least 3 medicine and chemistry to make most items, but reading scotty's and uri's diaries will raise each of those by 1 point so 2 points may be doable.

Health, mental, spot hidden and hearing should be maxed. Physical stats - strength, dexterity - should be high also.

Lockpick can be left at zero - all you need to pick a lock is time, even with no skill at all.

If you store all your extra weapons and guns and only carry a single shovel and a shortsword or large ax you can carry almost all the items you need in the game.

Completing Objective 1:

1) Leave house, go to the general store and get all items (candles, bags/bottles)
2) Go to Dice's house, open his safe and get items in his house (matches, ax, map)
3) Go to Scotty's house, open his safe and get items (scotty journal, various devices, bags/bottles) in his house
4) Go to the MIB house, get items (shovel, truth device, mission journal)
5) Go to the Black's Farm, use the shovel when underneath the willow tree to the east of the forest clump here to get the Brass Key
6) While at the Black Farm, go down the well, get items (old wine, charcoal), enter the Mafia Mansion and give the Boss the mission journal
7) Go to the MIB house, get the artifact and let the creature out (then get the artifact again)
8) Wait for Scotty to give you the contact device, go to the stones east of his house, and use it to complete Objective 1.

As for objective 2, I still haven't figured it out. Apparently you're supposed to read the Pisro Scroll (One comes from Dice's safe, the other from Uri's mansion) from on top of the Black Tower, but this alone doesn't seem enough to keep the creature under the stone disk from killing you.