1. Get CPU Killer program to slow down computer. (moslow comes to mind, google for it
)
2. Use CuteMouse (google for it too) for your mouse needs in DOS.
3. You have to set config.sys and autoexec.bat to adjust computer's memory to all of your needs. One of the sticky topics (most common problems) contains information needed to adjust all of those settings. If you need more help on this, you first have to post both of those files, memory screen shoot and required amount of EMS memory for that game.
Type ver to get DOS version.
Hope this helps.