Don't be afraid of isometric view.
These days everything has to be full 3D (by this I mean also full perspective view). In certain games - like the city building series Caesar or SimCity or even something like Transport Tycoon - having a fixed angle and no perspective distortion actually helps the player to assess distances (laying out the buildings precisely).
The real Fallout 3 (codename Van Buren) looked great despite using this view. And they did implement 3D engine, so isometric doesn't mean "spirtes". Games like Railroad Tycoon 3 or Trucks & Trains Tycoon were inferior to older versions as the player didn't benefit from the full 3D perspective view, but constantly fought with camera placement.
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