I haven't tried this one, but have had great time with a free remake "The Ur-Quan Masters". It has new musics (better quality, but but big download) and works without DosBOX. It is the same game, however. Well, atleast so I have read... If someone has problems downloading/running this one, here is the link:
http://sc2.sourceforge.net/
I think someone already posted the link, but am not sure.
As for how to run DosBOX:
You have to create new shortcut for DoxBOX.exe (right-click on and to choose "create shortcut" or something like that). Then you have to some properties of the shortcut (right-click the shortcut, choose "Properties". There are two paths (C:\abc\...) in there. One is the path of dosbox.exe, other is the folder the program dosbox runs is run from. You have to add path to the game you want Dosbox to run after the path of dosbox.exe.
Here is dosbox path with address to program called XYZ.xyz in folder sc2 in folder games on your c-drive after it. I don't know what is the name or type (.exe or .bat, probably) of the starcon2 program, you have to solve that yourself.
C:\DOSBox-0.61\dosbox.exe c:\games\sc2\XYZ.xyz
^^^^^^^^^^^^^^^^^^^
You also have to change the working folder so that when dosbox runs StarCon2 the program finds the files it is looking for.
To the 'working folder' or similar part of shortcut properties, put eg. c:\games\sc2\. Replace that with the path StarCon2 is installed in. DosBOX runs most Dos-programs. I think it would run Betrayal at Krondor, suberb, once commercial but nowadays free rpg too. Or so I wish... I never completed it. Two hard-drive formats, one new computer, one crash... :-(