I use this kind of sentence structure a lot when I'm writing. I'd be interested in the correct answer. Personally I usually use:
You, who seem to be a nice guy, play a lot of computer games. Upon reflection I believe that this is because if you split the sentence by the comma, and look at the second section, "who 'seems' to be a nice guy" can be a question if all you do is add a question mark at the end, where-as, if you eliminate the 's',: who seem to be a nice" really could only have one meaning unless you are in some inner-city ghetto down in manhattan...LOL (my attemp at a joke). I believe there is an english professor on this forum that could answer this question with finallity.....
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