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[Data]

it hasn't been updated for several years. The options it sets are not optimal for current versions of dosbox. So please a more updated one.
D-Fend Reloaded might be the one for you as it looks like D-fend but then more up to date

[The Fifth Horseman]

Or just take into account a few facts:
1. You can use [autoexec] section of the config files to do mount directories automatically, switch to different drive letters AND run programs.
2. You can declare multiple config files by editing the DOSBox shortcut.
3. DOSBox supports incremental shortcuts - so the second config only needs to contain the stuff that has to be changed.
4. You can have as many separate shortcuts as you like, and as many different config files as you like.

The point of this? With a few minutes of reading the instruction manual, you can make a shortcut that will automatically start up DOSBox with a specific choice of configuration settings, mount your games directory, switch to the mounted drive, enter the game directory and run it... and then exit DOSBox when the program terminates.
Once you've done it for the first time, setting up another game is at most 3 - 5 minutes.
Finding / making a spiffy icon to go with the shortcut is optional.

So far, I've got 130 games set up this way. It might be a little more complex than setting up the game in D-Fend, but lacks the problems caused by the "hands off" approach a lot of frontend programs promote in their users.
And once you're done, the game will launch with a simple double-click on the shortcut icon anyway.