"That doesn't seem to work..."
or
"I can't pick it up." [you click on the item again]
"No, seriously - I can't pick that up." [you click on the item again]
"Are you stupid? I can't pick it up!" [you click on the item again]
"Read it from my lips: I. Can't. Pick. It. Up." [you click on the item again]
"I give up." [your character turns its back to you and starts weeping.]
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