Well the GPU though might also alter your PSU and Motherboard choice, of course. A medium range GPU nowadays has a power requirement of 100-150 W on high load. Pair that up with a dual/quad core, 2 HDDs, a DVD drive and other peripherals you might put it, and the 500-550 W range for a PSU is the bare minimum. Might want to go over it a bit, since as I personally found out a month ago, as the PSU ages, it gives off less and less voltage, and one morning you find out that your computer gives you the middle finger because the PSU can't power all components.
And without trying to pick a fight, if you go with AMD, I'd recommend an ATI GPU (and yes, I loathe nVidia, sorry guys). a HD5770 if you want to go cheap, but if money is not a problem, one of the new series cards. If you really plan ahead, then two of the more powerful ones with SLI.
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Angelus Errare, where angels lose their way
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