In most cases (99.99%) you cannot replace the graphics card.
Much slower hard dirsk drives, most of them ship with 4200 drives, though some do with 7200. Even so, they are still slower than fast 3.5" drives.
Graphics cards, even of the same model as the desktop equivelant, are slower.
Memory can be usualy slower.
The CPU is slower, though for example the most recent Pentium Ms are faster per clock from their desktop Intel's, they are still slower in terms of speed. The myths that see 1.7Ghz run faster than 3.2 is that, a myth.
They are far more expensive gaming speed for gaming speed than a desktop.
The sound cards are much worse than what you can get for a gaming desktop. Though there are external options (USB), that would mean extra strain on the resources (USB). Still, they are not even close to say the new Soundblaster X-Fi range.
Motherboard/mainboard cannot be changed, thus upgrade in the future (say a couple of years) is a no no. So, if you spend lie 2000 GBP for a very fast gaming laptop, after two years (or later) you will just not be able to upgrade it to make it "new" again, thus need to buy another expensive laptop. Where if you buy say a desktop for 1400GBP that will probably anyway defeat in performance that laptop, and in 2 years time you want to upgrade say maiboard and cpu, it could cost you like another 300 GBP. Without considering of course if you want to upgrade the graphics card.
Usualy limited memory slots, which in most cases are full anyway.
If one thing goes wrong (graphics card, cpu, sound) you are stuck without a computer till replaced or fixed (which depending could take a long while), where with a desktop you can usualy not only diagnose the problem yourself but also replace the malfunctioning hardware yourself as quickly as possible. (or of course if you do not mind waiting, send it to the company that sold it to you for repairs)
Anyway, there are a few more reasons (for example limited monitors etc) but those are the main ones I think.
And yes, I did buy a gaming laptop a few years ago that I still use but I wish I had bought a faster, more powerful desktop with less money.
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