I'm running it on my USB hard drive (no fancy U3/3U/3D/3M/whatever involved). Works like a champ so far. You can even edit the config file so DOSBos automatically mounts your DOS games directory on the portable drive when it starts...no matter what drive letter it's been assigned.
These Portable versions are very good. I've been using Portable Firefox and Thunderbird for some time on my USB hard drive.
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