Sure. It's one of those games that auto-detects the specifications of the system. In my copy, SIMPSONS.BAT runs first INTROSEQ.EXE (the intro), then SIMPSONS.EXE (the game).
If you set DOSBox to Tandy, INTROSEQ.EXE won't work, you need to run SIMPSONS.EXE directly.
I've just uploaded my copy of the game, I made a TANDY.BAT to make things easier.
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