Best to use a scaler if your computer can handle it rather than using full screen. I use HQ2x (which might only be available in an official CVS build) but there are a bunch of others.
If you don't already, I recommend using a front-end with Dosbox like D-Fend Reloaded. It's easier to tinker with settings and lets you setup profiles for each game to easily load them in with whatever settings you want.
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