Too little info, sorry. Do you speak about spaceships, for example?
Star Control 2, for example, have multitude of ships and crews.
Frontier have crew management... of sorts.
Spelljammer have a crew too... but it's rather Fantasy than Sci-Fi... I am sure, there are much more such games around, but just now I cannot remember any (with space trading AND crew, I mean. Star Trek games, for example, all have space
travels and crew, but no trades).