While on vacation I overdose on booze and coffee. It turned out that booze makes you feel sick and depress and it doesn't help you feel picked up at all other than to make you an addict! Also, coffee in high doses will deplete some nutrients from your muscles; I ended up get a cramp and now it is sore for a while. I am in rehab in my own home. So the moral of the story is don't over do anything. Take it easy. Once in a while is okay.