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1. When Duke Leto heard that a sietch had been taken over by the Harkonnen, yelled and said that he has to go on a mission he may not come back from and simply vanished from the storyline.
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IIRC Jessica mentions his death later.
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3. When that annoying Shaddam couldn't leave me alone and just wanted more and more spice.
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Mine out the first bunch of territories before you go to the desert and start having visions. The plot won't progress, the Emperor won't demand any Spice for a while and you'll have plenty of time to prepare to leap onto the new territories you find after that.