Maybe using the "autolock mouse" option would help?
Without that option I have often had that I could use the mouse but that it had no effect in the game. In that case you also see a difference in the mouse cursor, it is not filled up like usual.
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A sickened, sensitive shadow writhing in hands that are not hands, and whirled blindly past ghastly midnights of rotting creation (Nyarlathotep, H.P. Lovecraft)
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