Shareaza downloads from several networks at once, but for ED2K network I advise eMule or MLDonkey.
Both support the serverless KAD network (which Shareaza doesn't) and MLDonkey also supports Overnet.
Also, DC++ is a very good one (provided you know the right hubs :). Fast and efficient... just one flaw: you'll run out of HDD space very fast after you start using it :P
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"God. Can't you people see I'm trying to commit a crime against science and nature here?"
-- Reed Richards
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