Actually, I would simply try it,
tymime.
I seen too many exotic problems with DOSBox, so any tiny bit can be important.
I know, for example, games that works in VGA-mode only with the specific videocard set.
Games that works in "official" build, but stops to work in "unofficial" (and vice versa).
Games that works only if you have from 100 to 500 cycles in DOSBox.
Not mentioning specific sound/space/memory management settings.
(Of course, I have no idea, if it will work with DOSBox - or D-Fend - in your case. But you need to try!
