Please give us more information: what is your OS, what version of DOSBox are you using? Are you using the version of the game that we have on site? Are you sure that you unzipped every files?
I just tryied Ascendancy on my computer (AB version). Works perfectly with DOSBox 0.72, and without a itch with VDMSound. The mouse issue don't even seem to be present with DOSBox...
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