Did you try to mount your hard drive and CD-Rom in DosBox and to install the game to your hard drive? Something like that below should do:
mount c c:\ (your hard drive)
mount d d:\ -t cdrom (the CD-Rom)
d:
(command to install the game, often install.exe)
Then, after the game is installed, usually the configuration program starts where you can set up the sound, memory etc. After that you can add the following lines under the [autoexec] section of dosbox.conf to run the game always you start DosBox, or just type them in DosBox each time if you prefer:
mount c c:\
c:
cd (game folder) (game folder is where you installed the game)
(command to run the game)
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