I doubt it will on DX9, which I played it on with full settings, but I have no clue how it runs on a Vista machine with DX10, very poorly if you don't have a godly machine I imagine.
Although that's rather stupid, I doubt %90 of the people that buy this game based on the graphics alone are going to be able to play it on the best settings, let alone with DX10 enabled, which voids the main draw of the game to the mainstream crowd.
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